Annual Congress on Neurology and Neuroscience March 14-15, 2019 Paris, France

Biography:

Serlet Sébastien completed a master's degree in neuropsychology in 2017 at the ScaLab laboratory (University of Lille, France) under the direction of Y. Coello. He was clinician at ERASME Hospital in Brussels where he discovers the R.O.G.E.R project. In 2018, he proposes the creation of the spin-off and gets funding in November to develop the program. He is now in charge of this project at the CRCN (Center for Research in Cognition and Neurosciences with A. Cleeremans) in Brussels.

Abstract:

R.O.G.E.R (Realistic Observation in Game and Experiences in Rehabilitation) is a virtual reality software. It was developed by a video game company (Fishing Cactus), in collaboration with researchers in neuropsychology (University of Brussels) and neuropsychologists (ERASME Hospital). The purpose of this software is to gather cognitive assessment scale and rehabilitation into a virtual house.

This software can be used in cognitive laboratories or rehabilitation services (i.e. neurology) by several therapists (neuropsychologists, physiotherapists, speech therapists, occupational therapists ...). It is also possible to combine the software with physiological measurements which can record and analyze data during each session (eye-tracker, electrodermal activity, electro-encephalogram ...). Thus, we can obtained precise measurements and guarantee the standardization of the evaluation.The R.O.G.E.R. software offers the possibility for patients to evolve in a safe environment (a complete house with 10 rooms, a garden and 300 objects), and the graphic quality enable a complete immersion and easier transfers in real life situations.

The software integrates an ergonomic scenario editor, which does not required sophisticated computer programming knowledge. The scenario editor enable therapists and researchers to create personalize scenarios for each patient.   

R.O.G.E.R promises a graphic quality, accessible for all therapists and neuroscientists, and offers the possibility to work with all cognitive functions and to provide new data for the clinical and the research field.

Biography:

Miriam Sanchez Reyes graduated in Social Work from the Complutense University of Madrid (Spain) in 2002, Master's Degree in Community Social Work, Management and Evaluation of Social Services 2007-2009 and, Doctorated (Ph. D) in Social Work in 2016. She is a specialist in Neurosciences by the University of Salamanca (Spain) and specialist in public and private management of health services by the European University Miguel de Cervantes.  Her training has been complemented by numerical courses and masters in various fields and in the present work in a line of theoretical research relating the Sanitary Social Work and the Neuroscience. She currently works as a hospital social worker in the Sureste University Hospital in the Community of Madrid and a collaborating teacher in the Master's Degree in Social Work at the Universitat Oberta de Catalunya.

She was the youngest person to receive the International Award for Excellence in Social Work in the framework of the III World Summit of Social Work held in Medellín, Colombia in 2016 and received the XX Scientific Award DTS (Documents in Social Work) in the modality theory and practice in 2016. She is the life member of the World Council of Social Work - OITS (International Organization of Social Work), belonging to the academic council, and member of the Board of the Spanish Scientific Society of Sanitary Social Work.

She has been working in the health field for 20 years developing different professional profiles, participated as speaker in numerous conferences, journeys and forums both nationally and internationally and published various articles.

Abstract:

The knowledge of modern Neuroscience has allowed to identify the origin of some neurodegenerative diseases, thus contributing to the development of more effective therapeutic and surgical strategies that are providing the affected people with greater independence and a better quality of life. In addition, this neuroscientific knowledge is providing relevant psychosocial knowledge and a better understanding of the human being, a field of action of Social Work.

Both the knowledge of modern Neuroscience and its contribution to social problems, as well as to behavioral phenomena and to the human condition at large, has important consequences for mental health and social well-being. It is therefore essential knowledge for the practice of health social workers.  Such neuroscientific knowledge provides a new way of examining and addressing problems and can help them to improve their interventions with the different people they assist.

Health social workers are the health field professionals who deal with the psychosocial aspects of patients; in this case, patients with neurodegenerative diseases such as Alzheimer's, Parkinson's, Multiple Sclerosis, Neuromuscular Diseases or ALS (amyotrophic lateral sclerosis). Therefore, it is essential that they have training on the most basic aspects of the human brain, such as: structure, functioning, how, the influence of psychosocial factors develops how it becomes ill or the treatments that can be used.

The pairing of Health Social Work and Modern Neuroscience means having more efficient and better trained professionals, and therefore, offering a higher quality psychosocial care to patients with neurodegenerative diseases.

Biography:

Dr. Mahmoud is a Senior Consultant Pediatric Neurologist and the Director of the Ketogenic Diet Program: National Neuroscience Institute, King Fahad Medical city. Dr. Mahmoud got: Fellowship of Pediatric Neurology: Hospital for Sick Children, Toronto, Canada, 2002 & Member-ship of Royal College& Diploma of Child health of Ireland, &Arab Board of Pediatrics, 1996, Damascus, Syria,1995 & Master of Pediatrics: Cairo, Egypt, 1990. For the last 13 years he is working in King Fahad Medical City. The center includes both residency and fellowship programs for pediatric Neurology. More than 15 candidates have been graduated and sent abroad. He is a supervisor of British Pediatric Neurology Association Course that runs in Riyadh, KSA. Many graduates got certified under his supervision. Dr. Mahmoud has more than 30 study and case report articles and he has been a speaker in many national and international meetings.. He runs a ketogenic diet program including 2 dieticians, a clinical pharmacist, a social worker and a coordinator.

Abstract:

Insulin dependent diabetes Mellitus (IDDM) is a common condition in children and adolescents worldwide and so is epilepsy. Recently, there were increasing reports suggesting a potential association between 1DDM and the occurrence of epilepsy. Their association might represent simply a chance to relate their underlying mechanisms. However, the cause-effect relationship is not well defined.  IDDM pediatric patients have characteristic clinical and biochemical features, including the positivity of glutamic acid decarboxylase antibodies (anti-GAD 65). Literature from other countries have shown the increased prevalence of seizure disorders in this group of patients. However, despite the high prevalence of this disease in Saudi Arabia, no studies have investigated this relationship. Moreover, literature lacks studies investigating IDDM characteristics contributing to this relationship, including anti-GAD 65. In this study we are aiming to determine the prevalence of epilepsy among IDDM children age <15 years old, and compare the positivity of anti-GAD 65 amongst them. Hence, we tried to establish the presence or absence of a relation between epilepsy in children with diabetes and presence of positive GAD65 Antibodies. This is a retrospective cross-sectional study, involving patients’ survey and files review. We randomly recruited around 300 pediatric patients (age <14) with IDDM from our cohort at pediatric endocrinology clinic of King Fahad Medical City (KFMC). A questionnaire was given to caregivers to determine any history of seizure disorders, followed by retrospective review of patients’ files for anti-GAD 65 positivity. In this talk we present our results and review literatures in this issue.

Biography:

Prof. Dr. Valentin has completed her Ph.D. at the age of 39 years from University of Sao Paulo School of Medicine and Duke University and postdoctoral studies from Harvard Medical School. She is the Principal Investigator of MentalPlus Project, the International and Multicentric Study linked at National Institute of Health (NIH) and registered in the clinicaltrials.gov under number NCT 02551952. She has published several papers in renowned journals and has been serving as an editorial board member of repute whose main topics are psychology, psychiatry, neurosciences, anesthesiology, neuropsychiatry, and cardiology.

Abstract:

With the growth of the world population, there is concern about the mental health of the people resulting from the daily agitation, from the demands of the social environment, from the academic and professional milieus. In addition to population growth, there is concern about the aging of this population and with this the mental diseases that affect cognition. But not only aging must concern the minds of neuroscientists as well as the healthy development of children who are discovering and training their cognitive abilities. Therefore, neuroscience is concerned with the human being at all stages of his life, as well as preserving in integrity his physical, emotional and mental health. Thinking about how to find a faster and fun way to evaluate the cognitive functions of humans from the age of 8 years to 80 years, the digital game MentalPlusÒ was created. This game aims to evaluate and also to rehabilitate the mnemonic, attentive, perceptive and executive functions in just 25 minutes which characterizes it different from the other neuropsychological tests that require a long time, sometimes up to three hours to evaluate all these functions together and the most interesting in this game is that it is digital, fun and self-applicable. The MentalPlus digital game provides the evaluator with final graphs of the player's results allowing the understanding of the person's performance during the phases of the game in each evaluated function. The digital game MentalPlus is being studied in several research centers, national (Brazil) and international. Studies in clinical trials are being performed with the MentalPlus Digital Game to investigate its efficiency in evaluating cognitive functions such as postoperative recovery after anesthetic-surgical procedures, after a cardiorespiratory arrest, pathologies such as Autism, Attention Deficit Hyperactivity Disorder (ADHD), Depression, Perthes' disease and academic learning difficulties. The MentalPlus digital game is already in several places in the world: America, Europe, Africa, and Asia. We are interested in new partnerships. If you are a researcher and you are interested in collaborating with us, welcome, contact us!

Biography:

Abstract:

Biography:

Prof. Emeritus Stavros J Baloyannis was born in Thessaloniki, Greece. He graduated from the School of Medicine of Aristotelian University of Thessaloniki, Postgraduate training (a) in Neurology in Aristotelian University and Institute of Neurology, Queen Square, London, (b) in Neuropathology in Institute of Neurology, Queen Square, Catholic University of Louvain, University of Pennsylvania, Philadelphia, USA (c) in Neurootology and Neuropathology of Auditory pathway in Harvard University, (d). Neuropathology and Experimental Neurology, University of Pennsylvania, (e) Neuroimmunology, Yale University. Member of 40 scientific societies in Greece and abroad. Honorary Member of the Academy of Hellenic Air Forces. President of the Society for the amelioration of the quality of life in chronic neurological diseases. President of the Orthodox Medical Association for support of health and medical education in Africa. He was a visiting professor at Tufts University, Democratic University, Aristotelian University, School of Theology, Aristotelian University, School of Philosophy. Author of 28 textbooks on Neurology, Neuropathology, Neuropsychology and of 678 papers, published in Greek and International Journals on Neurology, Neuropathology, Neuroimmunology and Neurotics. Head of the 1st Department of Neurology, Aristotelian University for 20 years (1992-2011).Emeritus Professor of Neurology, Aristotelian University, Thessaloniki, Greece. Director of Research Institute for Alzheimer’s disease, Iraklion, Langada.

Abstract:

Alzheimer’s disease is a neurodegenerative disorder resulting in gradual decline of mental faculties leading to an almost vegetative state eventually. The study of the synaptic alterations and the dendritic and spine pathology in cortical and subcortical neurons is crucial for the correlation of the steps of the mental deterioration with the morphological changes which may disrupt the harmonious communication between neurons, causing serious mental deficits. In early case of Alzheimer’s disease we attempted to study the morphology of synapses and to estimate the numerical density of synapses per dendritic arbor. In addition we studied the morphology of the dendritic spines, estimating also the spinal density per dendritic branch. The study is based on stereological methods applied in light and electron microscopy on specimens of the cerebellar cortex and the hypothalamus of brains derived from patients who suffered from Alzheimer’s disease in early stages. The numerical density of synapses per dendritic branch was estimated on the basis of dissector counting method. We applied also the physical dissector technique on serial sections studied in transmission electron microscopy. The study revealed tremendous loss of dendritic branches, spines and synapses in AD brains in comparison with normal controls. The synaptic loss in the cerebellar cortex concerned mostly the parallel fibers and the Purkinje cell dendrites. In the hypothalamus the neurons of the suprachiasmatic nucleus demonstrated the most impressive decrease of synaptic density per dendritic branch. The morphological and morphometric alterations estimated by stereological techniques confirm that the mental decline coincides  with the numerical decline of the synapses in cortical and subcortical neuronal networks in Alzheimer’s disease.

Biography:

Mojtaba Mafi is a physician/Medical Doctor. He received M.D. degree from Tehran university school of Medicine with honors and passed successfully many post graduate Medical education programs approved by Medical Sciences University. He worked clinically in Neurosurgery ward Shariati hospital for Thesis on Brain tumors and Meningioma for 6 years till 2008. He is now active in clinical setting and scientific field. Dr Mojtaba Mafi is invited speaker in Global and European neurosurgery and neurology conferences in Rome, Italy and London. He is invited editorial board member of psychology and neuroscience journal. He is speaker of world congress on neuronal synchronization, London 2018 and speaker of International Neuro oncology conference in Dubai, September 2018. He is honourable speaker of 26th International Neurology conference in Japan. Dr Mojtaba Mafi is Board member of International journal of psychology and neuroscience. Dr Mafi is Speaker of 5th annual conference on stroke and Neurodisorders, Turkey, November 2018.

Abstract:

We studied on meningioma among 614 patients with Brain tumor (consists of meningioma, glioma and pituitary tumor). 145 patients had meningioma. Our results are in various topics:

1.  Clinical features of meningioma
2.  Anatomical distribution
3.  Radiation induced meningioma
4.  Meningioma and foster Kennedy syndrome
5.  Meningioma and pseudo foster Kennedy syndrome
6.  Multiple meningioma
7.  Post traumatic and skull fracture meningioma
8.  Cutaneous meningioma
9.  Meningioma and DVT
10. Trigeminal neuralgia and meningioma
11. Recurrent meningioma
12. Meningioma and thrombosis

We are going on to continue this study. This research project has been held in neurosurgery ward Shariati Hospital and had been scientifically registered. We studied during 6 years on meningioma and in this abstract article, we present a patient with Brain stroke symptoms. In this regard, we aimed to review the unusual sign and symptoms of meningioma, e.g. behavioral change, MS like symptom and symptoms of cerebral infarction. All mentioned signs and symptoms initially seems to be unusual for Brain tumor diagnosis, so we found among our study sample, 4 patients under psychiatric treatment and psychological consultation without any Brain imaging study. Therefore, meningioma can present with varies types of neurological and non-neurological symptoms. Meningioma is an extra axial Brain tumor. In fact, meningioma can push the brain tissue, leads to Brain compression as well as intra cranial portion of internal carotid artery. Since meningioma can involve intra cranial portion of the internal carotid artery, the cerebral blood flow slows and, in this status, a clot formation can occur. Various anatomical types of meningioma like sphenoid wing, frontobasal, temporobasal, olfactory groove can compress intra cranial portion of the internal carotid artery.

We report one case of meningioma presenting with cerebral stroke. A 30 years old woman with right upper extremity weakness and right hand numbness, in physical examination, right hand force was 1/5 worsening during 4 weeks. MRI study reveals cavernous area meningioma and the patient after radiation therapy improved completely. We dedicate radiologic specificities and patient's angiography and discussion of anatomical and clinical properties and behaviors of meningioma in this current case, at oral presentation time. In this case, we had done sufficient modalities to rule out hypercoagulable state or any source of emboli.

Biography:

Eshan Khan is PhD Research Scholar under supervision Dr. Amit Kumar in Discipline of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, India. He has joined Amit Kumar’s lab in July, 2014 and working on therapeutic approaches targeting (CAG)^exp RNA that causes neurological disorders like Huntington’s Disease (HD) and Spino Cerebellar Ataxia (SCAs).

Abstract:

Huntington’s disease (HD) is a neurodegenerative disorder that is caused by abnormal expansion of CAG repeats in the HTT gene. The transcribed mutant RNA contains expanded CAG repeats that translate into a mutant huntingtin protein. This expanded CAG repeat also causes mis-splicing of pre-mRNA due to sequestration of muscle blind like-1 splicing factor (MBNL1), and thus both of these elicit the pathogenesis of HD. Targeting the onset as well as progression of HD by small molecules could be a potent therapeutic approach. We have screened a set of small molecules to target this transcript and found Myricetin, a flavonoid, as a lead molecule that interacts with the CAG motif and thus prevents the translation of mutant huntingtin protein as well as sequestration of MBNL1. Here, we report the first solution structure of the complex formed between Myricetin and RNA containing the 5′CAG/3′GAC motif. Myricetin interacts with this RNA via base stacking at the AA mismatch. Moreover, Myricetin was also found reducing the proteo-toxicity generated due to the aggregation of polyglutamine, and further, its supplementation also improves neurobehavioral deficits in the HD mouse model. Our study provides the structural and mechanistic basis of Myricetin as an effective therapeutic candidate for HD and other polyQ related disorders.

Biography:

Arsal Acarbas has completed his Phd from Trakya University of Medical Faculty at 2001. And then postdoctoral studies from Vakıf Gureba Egitim ve Arastırma Hospital from 2002 to 2007. And he is still working at Mugla University of  Medical School as Asistant Professor.

Abstract:

Objective: Previous studies have shown that troponin is a valuable predictor of perioperative complications after non-cardiac surgery. However, the relation of preoperative troponin levels with perioperative adverse events have not been well described in patients undergoingneurosurgical procedures. This study aimed to evaluate the impact of preoperative high-sensitivity cardiac troponin T (hs-cTnT) levels on outcome of patients undergoing neurosurgical procedures.

Methods:  A total of 2519 patients who were aged over 18 years and undergoing elective neurosurgery between December 2014 and December 2018, were retrospectively evaluated. Patients’ information, including medical and demographic data, routine preoperative laboratory tests including hs-cTnT levels were collected to assess the association between these factors and perioperative adverse events.

Results: Perioperative adverse events occurred in 251 (10.0%) patients. Older patients and those with more comorbid conditions tended to have a higher rate of perioperative adverse events. The preoperative hs-cTnT levels were significantly higher in the individuals that experienced complicated in-hospital course than in those who did not (21.6±8.2 vs 6.3±3.1 ng/L, p < 0.001). Multivariate analysis showed that age (OR: 2.33, 95% CI 1.16-4.35, p<0.01), presence of diabetes (OR: 3.13; 95% CI: 1.15-6.32; p =0.004), and preoperative hs-cTnT > 18.3 ng/L (OR 4.51, 95% CI 2.34–7.82, p < 0.001) were significant and independent predictors of perioperative adverse events.

Conclusion: This study showed that higher preoperative hs-cTnT is associated with perioperative adverse events in adult patients undergoing elective neurosurgery.

Biography:

Conor Gillespie is a third year medical student at the University of Liverpool, UK. His interests in Neurosurgery include Traumatic Brain Injury, prognosticating TBI using age, CRASH and IMPACT models, the effect of admission to a tertiary neurosurgical centre and the outcomes of elderly TBI patients. He works closely with the Consultant Neurosurgeons at the Walton Centre (The only specialist hospital trust in the UK dedicated specifically to Neurology and Neurosurgery) on a variety of research areas, ranging from TBI, Meningioma management and Cranioplasty material development. He is also an academic rep for NANSIG (Neurology and Neurosurgery Interest group, UK).

Abstract:

Introduction: Both CRASH and IMPACT models have been developed in recent years to prognosticate Traumatic Brain Injury (TBI). However, there is no clear evidence as to how acceptance for Neurosurgical intervention to tertiary centres affects outcome compared to other centres. There is also predictive uncertainty with regards to if acceptance affects the ability of CRASH and IMPACT to prognosticate TBI.

Methods: Patients referred to a tertiary neuroscience centre from December 2014-January 2016 with a suspected TBI were retrospectively examined. For each model, the predicted survival and overall outcome were compared to the actual outcome on admission and at 6 months post injury, stratified by patient age and acceptance for Neurosurgical intervention.

Results: 161 patients met the initial criteria; mean age 65 yrs (SD=21). Both CRASH and IMPACT correctly predicted 6-month mortality rates and functional outcomes in most patients (range 61.7-82.4%), with better predictive performance for patients not accepted to the centre (range 84-98%). There was also no significant difference in the initial survival of elderly patients if accepted (78% [95% CI 50.6-104] vs. 81% [95% CI 67.8-94.8] but were lower for those not accepted (24% [95% CI 4.2-43.7] vs. 76% [95% CI 63.5-88.5], p=0.027).

Discussion: The lesser ability of CRASH and IMPACT models to predict outcomes when accepted suggests that acceptance to specialist centres may be able to improve outcome. Patients >65 years also had good survival rates on admission and at 6 months if accepted. This suggests more optimistic treatment and acceptance of appropriate patients should be considered.

Biography:

Raquel Elisabeth Dumaszak is a graduate in psychology with a master's degree from the University of Brasilia and currently working as a teacher at UniOpet- Curitiba, Brazil 

Abstract:

Sleep is essential for mental and physical health, and its alterations or deprivation (SD) can alter several behavioral and cognitive aspects, such as memory, for example. In recent years, much has been observed regarding the diversity of alternatives used to interfere in sleep time. Alcohol, for example, is related as an alternative to manipulate sleep and, in times of leisure, is used to reduce levels of anxiety and stress. However, many are the contradictory evidences regarding the interaction (EtOH) x sleep, and its influences on behavior and cognition, being the object of study of this work, it was observed the behavioral response of rats, in experimental models equivalent to anxiety and memory: open field test (locomotion), elevated plus maze (EPM - anxiety) and “step down” inhibitory avoidance (memory). In a general context, it was observed that the SD, induced the animals to longer dodging time which suggested increased learning, while this experimental condition varied the results for anxiety. EtOH, on the other hand, influenced the reduction of anxiety and learning outcomes according to the association of the experimental conditions, but it was concluded that even in acute and low dose consumption, modify memory, learning and anxiety.