Microglia and astrocytes
Microglia and astrocytes are two crucial types of glial cells in the central nervous system (CNS). They perform essential supportive, protective, and regulatory functions for neurons while also playing significant roles in development, homeostasis, and response to injury or disease.
Microglia: The Brain’s Immune Cells:
A. Origin and Characteristics
- Microglia are the resident immune cells of the CNS, derived from embryonic yolk sac progenitors, unlike other CNS cells that arise from the neural tube.
- They are dynamic cells that continuously monitor the CNS for signs of infection, injury, or disease.
- Microglia make up 10-15% of all CNS cells.
B. Functions of Microglia
-
Immune Surveillance:
- Microglia constantly patrol the CNS for pathogens, debris, or signs of injury.
- They initiate immune responses by releasing cytokines and chemokines.
-
Phagocytosis:
- They engulf and remove dead cells, debris, and pathogens to maintain CNS homeostasis.
-
Synaptic Pruning:
- During brain development, microglia help refine neural circuits by removing excess or weak synapses through complement-mediated signaling (e.g., C1q and C3 proteins).
-
Neurogenesis:
- Microglia support the development and maturation of neurons, especially in regions like the hippocampus.
-
Inflammatory Response:
- Microglia can adopt pro-inflammatory (M1 phenotype) or anti-inflammatory and reparative (M2 phenotype) states, depending on the context.
- Dysregulation of this response is implicated in various neurodegenerative and psychiatric disorders.
-
Interaction with Astrocytes:
- Microglia work in concert with astrocytes to modulate inflammation, neuronal survival, and repair processes.
C. Microglia in Disease
- Neurodegenerative Diseases:
- Alzheimer's Disease: Microglia are activated by amyloid-β plaques, releasing pro-inflammatory cytokines, which can exacerbate neuronal damage.
- Parkinson's Disease: Microglial overactivation in response to α-synuclein aggregates contributes to dopaminergic neuron loss.
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- Neurological Disorders and Stroke - NEUROLOGY-2025 (UK)
- Neurological Disorders in Aging Populations - NEUROSCIENCE_2025 (France)
- Neurological Education and Advocacy - Neurology Conference 2025 (France)
- Neurological Impact of Sleep Disorders - Cognitive Neuroscience 2025 (Switzerland)
- Neurological Implications of COVID-19 - Cognitive Neuroscience 2025 (Switzerland)
- Neurological Infections - Neurology Conference 2025 (France)
- Neurological Infections - BRAIN DISORDER - 2025 (France)
- Neurological Infections - Stroke Summit 2025 (Canada)
- Neurological Manifestations of Climate Change - Neurology Conference 2025 (France)
- Neurological Rehabilitation & Genetic Counseling - Neurogenetics 2025 (Canada)
- Neurology - Neuroscience-2025 (UAE)
- Neurology - NEURO SCIENCE CONGRESS 2025 (France)
- Neurology - NEURO CONGRESS 2025 (UK)
- Neurology - NEUROLOGISTS MEET 2025 (Netherlands)
- Neurology - Stroke Summit 2025 (Canada)
- Neurology and Neuroscience - Neuroscience Congress 2025 (Canada)
- Neurology and Neurosurgery - Stroke Meeting 2025 (France)
- Neurology Education - NEUROLOGISTS MEET 2025 (Netherlands)
- Neurology of Pregnancy - Neurology Conference 2025 (France)
- Neurology of Systemic Disease - Neurology Conference 2025 (France)
- Neuromodulation - Neurology Conference 2025 (France)
- Neuromodulation and Brain Stimulation Therapies - BRAIN DISORDER - 2025 (France)
- Neuromuscular diseases - NEUROLOGISTS MEET 2025 (Netherlands)
- Neuromuscular Disorders - Neurology Conference 2025 (France)
- Neuromuscular Disorders - Child Neurology 2025 (France)
- Neuromuscular Disorders - NEURO CONGRESS 2025 (UK)
- Neuromuscular Respiratory - Neurology Conference 2025 (France)
- Neuropathic Pain Management - NEURO CONGRESS 2025 (UK)
- Neuropathology - NEUROLOGISTS MEET 2025 (Netherlands)
- Neuropathology and Mechanisms of Brain Injury - NEUROSCIENCE_2025 (France)
- Neuropathology of Alzheimer's disease - Euro Dementia 2025 (Germany)
- Neuropharmacology - Neurology Conference 2025 (France)
- Neuropharmacology - NEURO SCIENCE 2025 (Czech Republic)
- Neuropharmacology - NEUROLOGISTS MEET 2025 (Netherlands)
- Neuropharmacology - Neurogenetics 2025 (Canada)
- Neuropharmacology - Stroke Summit 2025 (Canada)
- Neuropharmacology and Neurochemistry - NEUROLOGY-2025 (UK)
- Neuropharmacology and Neurotherapeutics - NEUROSCIENCE_2025 (France)
- Neuropharmacology and Neurotoxicology - Neurological Disorders 2025 (Netherlands)
- Neuropharmacology and Therapeutic Innovations - BRAIN DISORDER - 2025 (France)
- Neurophysiological Effects of Neuromodulation - Neurophysiology 2025 (Germany)
- Neurophysiology and Neurodegeneration - Stroke Meeting 2025 (France)
- Neurophysiology, Neuroimaging and Radiology - Neuroscience Congress 2025 (Canada)
- Neurophysiology, Neuroimaging and Radiology - Stroke Summit 2025 (Canada)
- Neuroplasticity - Neurology Conference 2025 (France)
- Neuroplasticity - Neuroscience Congress-2025 (France)
- Neuroplasticity & Neurorehabilitation - NEUROLOGISTS MEET 2025 (Netherlands)
- Neuroplasticity and Brain Development - Neurophysiology 2025 (Germany)
- Neuroplasticity and Brain Recovery - Neuro Surgery 2025 (UK)
- Neuroplasticity and Brain Rehabilitation - Cognitive Neuroscience 2025 (Switzerland)
- Neuroplasticity and Brain Repair - NEURO CONGRESS 2025 (UK)
- Neuroplasticity and Neurorehabilitation - Neuroscience Congress 2025 (Canada)
- Neuroplasticity and Rehabilitation - Neurological Disorders 2025 (Netherlands)
- Neuroprosthetics: Advancing Mobility and Cognition - Neurological Disorders 2025 (Netherlands)
- Neuroprotection and Neuroregeneration - Neurology Conference 2025 (France)
- Neuropsychiatric Complications of COVID-19 - Neurophysiology 2025 (Germany)
- Neuropsychiatric Effects of COVID-19 - NEUROSUMMIT 2025 (France)
- Neuropsychiatry - NEURO CONGRESS 2025 (UK)
- Neuropsychiatry - Stroke Summit 2025 (Canada)
- Neuropsychology - Neuroscience-2025 (UAE)
- Neuropsychology - NEURO SCIENCE 2025 (Czech Republic)
- Neuropsychology and Addiction - NEUROLOGY-2025 (UK)
- Neuropsychology and Neurorehabilitation - Neurology Conference 2025 (France)
- Neuropsychology of Traumatic Brain Injury - Cognitive Neuroscience 2025 (Switzerland)
- Neuroradiology - Neurology Conference 2025 (France)
- Neuroregeneration - Neurology Conference 2025 (France)
- Neurorehabilitation - Child Neurology 2025 (France)
- Neurorehabilitation - NEURO SCIENCE CONGRESS 2025 (France)
- Neurorehabilitation - NEURO SCIENCE 2025 (Czech Republic)
- Neurorehabilitation - NEURO CONGRESS 2025 (UK)
- Neurorehabilitation and Post-Surgical Care - Neuro Surgery 2025 (UK)
- Neuroscience - NEUROSUMMIT 2025 (France)
- Neuroscience - Neuroscience Congress-2025 (France)
- Neuroscience - NEURO SCIENCE CONGRESS 2025 (France)
- Neuroscience - Alzheimers-2025 (France)
- Neuroscience and Artificial Intelligence - NEUROLOGY-2025 (UK)
- Neuroscience and Mental Health - Mental Health Congress 2025 (France)
- Neuroscience and Neuroimaging - Stroke Meeting 2025 (France)
- Neurosurgery - Neuroscience-2025 (UAE)
- Neurosurgery - Neurology Conference 2025 (France)
- Neurosurgery - NEUROLOGISTS MEET 2025 (Netherlands)
- Neurosurgery - Stroke Summit 2025 (Canada)
- Neurosurgery and Spine - NEUROLOGY-2025 (UK)
- Neurosurgery and Spine - Cognitive Neuroscience 2025 (Switzerland)
- Neurosurgery and Trauma Care - Neurological Disorders 2025 (Netherlands)
- Neurosurgery for Psychiatric Disorders - Neuro Surgery 2025 (UK)
- Neurosurgery Innovations and Techniques - NEUROSCIENCE_2025 (France)
- Neurosurgical Robotics and Artificial Intelligence (AI) - Neuro Surgery 2025 (UK)
- Neurotechnologies and Brain-Machine Interfaces - NEURO CONGRESS 2025 (UK)
- Neurotechnology - Neuroscience Congress-2025 (France)
- Neurotechnology and Brain Imaging - NEURO SCIENCE 2025 (Czech Republic)
- Neurotransmitters and Neuromodulators - NEURO SCIENCE 2025 (Czech Republic)
- Neurotrauma - NEURO SCIENCE 2025 (Czech Republic)
- Neurovascular Biology - NEURO SCIENCE 2025 (Czech Republic)
- Neurovascular Biology - NEURO SCIENCE 2025 (Czech Republic)
- Neurovascular Biology - NEURO SCIENCE 2025 (Czech Republic)
- Neurovascular Disorders - NEURO CONGRESS 2025 (UK)
- Neurovascular Disorders and Stroke Prevention - Neurology Congress 2025 (UK)
- Neurovascular health - Neurophysiology 2025 (Germany)
- Neurovascular Medicine and Stroke Innovations - Neurological Disorders 2025 (Netherlands)
- Non-Invasive Neuromodulation - Neurology Conference 2025 (France)
- Novel Treatment Strategies - BRAIN DISORDER - 2025 (France)
- Nursing and Neuroscience - Neurogenetics 2025 (Canada)
- Nursing and Neuroscience - Neurology Conference 2025 (France)
- Nursing and Neuroscience - NEUROLOGISTS MEET 2025 (Netherlands)
- Nutrigenomics and Precision Medicine - NEURO CONGRESS 2025 (UK)
- Ophthalmology and Visual Neuroscience - NEUROLOGY-2025 (UK)
- Paediatric Neurology - NEURO CONGRESS 2025 (UK)
- Paediatric Neurology and Epilepsy - NEUROLOGY-2025 (UK)
- Pain and Sensory Neuroscience - NEURO SCIENCE 2025 (Czech Republic)
- Pain Mechanisms and Management - Neurology Conference 2025 (France)
- Pain Neuroscience: Understanding and Relief - Neurological Disorders 2025 (Netherlands)
- Parkinson's disease - Neuroscience Congress-2025 (France)
- Parkinson’s Disease and Movement Disorders - Neurological Disorders 2025 (Netherlands)
- Parkinson’s Diseases and Dementia - Euro Dementia 2025 (Germany)
- Pathophysiology of Dementia - Euro Dementia 2025 (Germany)
- Patient Care and Rehabilitation - BRAIN DISORDER - 2025 (France)
- Pediatric and Adolescent Mental Health - EURO MENTAL DISORDER 2025 (France)
- Pediatric and Adult Epilepsy Transition - Epilepsy 2025 (Spain)
- Pediatric Epilepsy - Epilepsy 2025 (Spain)
- Pediatric Neurology - Neurophysiology 2025 (Germany)
- Pediatric Neurology - Neurology Conference 2025 (France)
- Pediatric Neurology - NEURO SCIENCE CONGRESS 2025 (France)
- Pediatric Neurology - NEUROLOGISTS MEET 2025 (Netherlands)
- Pediatric Neurology - Neurogenetics 2025 (Canada)
- Pediatric Neurology - Neuroscience Congress 2025 (Canada)
- Pediatric Neurology - Stroke Summit 2025 (Canada)
- Pediatric Neurology - NEUROSCIENCE_2025 (France)
- Pediatric Neurology and Epilepsy - Cognitive Neuroscience 2025 (Switzerland)
- Pediatric Neurology: Disorders and Innovations - Neurological Disorders 2025 (Netherlands)
- Pediatric Neuromuscular Disorders - Neurology Conference 2025 (France)
- Pediatric Neurosurgery - Child Neurology 2025 (France)
- Pediatric Neurosurgery - Neuro Surgery 2025 (UK)
- Pediatric Sleep Solutions - SLEEP DISORDER 2025 (Netherlands)
- Peripheral Nerve & Motor Neuron Disorders - Neurology Conference 2025 (France)
- Peripheral Neuropathy and Pain Management - Neurophysiology 2025 (Germany)
- Personalized Medicine for Neurological Disorders - Neurology Conference 2025 (France)
- Personalized Sleep Therapies - SLEEP DISORDER 2025 (Netherlands)
- Pharmacological Advances in Dementia Treatment - Euro Dementia 2025 (Germany)
- Pioneering Techniques in Awake Craniotomy - Neuro Surgery 2025 (UK)
- Post-Traumatic Stress Disorder (PTSD) - NEUROSUMMIT 2025 (France)
- Post-Traumatic Stress Disorder (PTSD) - DEPRESSION CONGRESS 2025 (France)
- Precision Medicine and Genetics - Neurology Conference 2025 (France)
- Psychiatric Neuroscience - NEURO SCIENCE 2025 (Czech Republic)
- Psychiatric neuroscience - Neuroscience Congress-2025 (France)
- Psychiatry - Mental Health Congress 2025 (France)
- Psychiatry and Psychology - Neurology Conference 2025 (France)
- Psychiatry and Psychology - NEURO SCIENCE CONGRESS 2025 (France)
- Psychiatry and Psychology - NEUROLOGISTS MEET 2025 (Netherlands)
- Psychiatry and Psychology - Neurogenetics 2025 (Canada)
- Psychological disorders - Neuroscience-2025 (UAE)
- Psychological Research - Mental Health Congress 2025 (France)
- Psychology - Neuroscience-2025 (UAE)
- Psychology, Cell & Molecular Biology - NEUROLOGY-2025 (UK)
- Psychoneuroimmunology - NEUROSUMMIT 2025 (France)
- Psychopharmacology - NEURO SCIENCE CONGRESS 2025 (France)
- Psychopharmacology - DEPRESSION CONGRESS 2025 (France)
- Psychosocial Aspects of Child Neurology - Child Neurology 2025 (France)
- Psychosomatic Disorders - Neuroscience-2025 (UAE)
- Psychosomatic Disorders - Neurology Conference 2025 (France)
- Psychotherapy - Neuroscience-2025 (UAE)
- Psychotherapy and Counselling - Mental Health Congress 2025 (France)
- Public Health Initiatives and Advocacy - Alzheimers-2025 (France)
- Rapid Sleep Diagnostics - SLEEP DISORDER 2025 (Netherlands)
- Rare Neurological Disorders and Case Studies - Neurological Disorders 2025 (Netherlands)
- Rehabilitation and Neuroplasticity - NEUROSCIENCE_2025 (France)
- Rehabilitation and Restorative Therapy in Stroke - Stroke Summit 2025 (Canada)
- Research and Emerging Trends of Depression - DEPRESSION CONGRESS 2025 (France)
- Risk factor and Prevention of Stroke - Stroke Summit 2025 (Canada)
- Risk factors, Diagnosis, Medications, and Recovery - Stroke Meeting 2025 (France)
- Robotic Neurosurgery - NEURO SCIENCE CONGRESS 2025 (France)
- Robotic Neurosurgery - Neuroscience Congress 2025 (Canada)
- Schizophrenia - Neuroscience Congress-2025 (France)
- Schizophrenia and Psychotic Disorders - NEUROSUMMIT 2025 (France)
- Screen Time Effects - SLEEP DISORDER 2025 (Netherlands)
- Shift Worker Sleep Tips - SLEEP DISORDER 2025 (Netherlands)
- Skull Base Surgery: Techniques and Outcomes - Neuro Surgery 2025 (UK)
- Sleep and Circadian Rhythms - NEURO SCIENCE 2025 (Czech Republic)
- Sleep and the Nervous System - Neurology Conference 2025 (France)
- Sleep Apnea Device Overview - SLEEP DISORDER 2025 (Netherlands)
- Sleep disorder - Mental Health Congress 2025 (France)
- Sleep Disorders - Neurology Conference 2025 (France)
- Sleep Disorders - BRAIN DISORDER - 2025 (France)
- Sleep Disorders and Circadian Neuroscience - NEUROSCIENCE_2025 (France)
- Sleep Disorders and Circadian Rhythm - NEURO CONGRESS 2025 (UK)
- Sleep Disorders and Neurology - Neurophysiology 2025 (Germany)
- Sleep Disorders and Neurology - NEURO SCIENCE CONGRESS 2025 (France)
- Sleep Disorders: Pathophysiology and Management - Neurological Disorders 2025 (Netherlands)
- Sleep Hygiene Essentials - SLEEP DISORDER 2025 (Netherlands)
- Sleep in Mental Health - SLEEP DISORDER 2025 (Netherlands)
- Sleep Myths vs. Facts - SLEEP DISORDER 2025 (Netherlands)
- Social Isolation and Loneliness - DEPRESSION CONGRESS 2025 (France)
- Social psychology - Neuroscience-2025 (UAE)
- Spinal Cord Disorders - Neurology Conference 2025 (France)
- Spinal Cord Injuries: Innovations and Rehabilitation - Neurological Disorders 2025 (Netherlands)
- Spinal Cord Injuries: Surgical Management and Rehabilitation - Neuro Surgery 2025 (UK)
- Spine and Spinal Disorders - Neurology Conference 2025 (France)
- Spine and Spinal disorders - NEURO SCIENCE CONGRESS 2025 (France)
- Spine and Spinal disorders - Neuroscience Congress 2025 (Canada)
- Spirituality, Mindfulness, and Mental Health - NEUROSUMMIT 2025 (France)
- Sports Neurology - Neurology Conference 2025 (France)
- Stem Cell Therapy and Regenerative Medicine in Neurosurgery - Neuro Surgery 2025 (UK)
- Stem Cells Role in Neuro-Biological Treatment - NEUROLOGY-2025 (UK)
- Stigma and Mental Health - EURO MENTAL DISORDER 2025 (France)
- Stress and Insomnia - DEPRESSION CONGRESS 2025 (France)
- Stress and Sleep Connection - SLEEP DISORDER 2025 (Netherlands)
- Stroke - Stroke Summit 2025 (Canada)
- Stroke and Cerebrovascular Diseases - Stroke Meeting 2025 (France)
- Stroke and Cerebrovascular Disorders - BRAIN DISORDER - 2025 (France)
- Stroke and Cerebrovascular Disorders - NEUROSCIENCE_2025 (France)
- Stroke and Neurological Disorders - Neuroscience Congress 2025 (Canada)
- Stroke and recovery - Neuroscience Congress-2025 (France)
- Stroke Management and Cerebrovascular Disorders - Neurological Disorders 2025 (Netherlands)
- Stroke Rehabilitation and Brain Hemorrhage - Stroke Meeting 2025 (France)
- Stroke risk, phenotypes, and death in COVID-19 - Stroke Meeting 2025 (France)
- Substance Abuse and Mental Health - EURO MENTAL DISORDER 2025 (France)
- Suicidal Ideation and Behaviour - DEPRESSION CONGRESS 2025 (France)
- Suicide Prevention Strategies - EURO MENTAL DISORDER 2025 (France)
- Technological Innovations in Mental Health - EURO MENTAL DISORDER 2025 (France)
- The Impact of Epilepsy on Cognitive Function and Quality of Life - Epilepsy 2025 (Spain)
- The Impact of Epilepsy on Cognitive Function and Quality of Life - Epilepsy 2025 (Spain)
- The Microbiome and the Nervous System - Neurology Conference 2025 (France)
- The Psychological Impact of Sexual Abuse - DEPRESSION CONGRESS 2025 (France)
- The Role of Neurostimulation in Epilepsy Management - Epilepsy 2025 (Spain)
- The Role of Neurostimulation in Epilepsy Management - Epilepsy 2025 (Spain)
- The Role of Seizure Monitoring and Technology in Epilepsy Management - Epilepsy 2025 (Spain)
- Traumatic brain injury - Neuroscience Congress-2025 (France)
- Traumatic Brain Injury (TBI) - NEURO CONGRESS 2025 (UK)
- Traumatic Brain Injury (TBI) and Neurotrauma - Neuro Surgery 2025 (UK)
- Vascular Dementia - Euro Dementia 2025 (Germany)
- Woman’s Mental Health - Neurophysiology 2025 (Germany)
- Women's Mental Health - EURO MENTAL DISORDER 2025 (France)
- Women’s Sleep Health - SLEEP DISORDER 2025 (Netherlands)
- Workplace Mental Health - EURO MENTAL DISORDER 2025 (France)
- Workplace Mental Health - DEPRESSION CONGRESS 2025 (France)